细胞生长是细胞周期的一项必要条件.尽管常常认为增长是细胞周期的独立的位置,这种关系还没有被仔细研究.在这里,我们表明,在芽殖酵母,在细胞周期细胞的增殖能力在变化.我们发现,细胞G1期生长速度比其他细胞周期阶段更快.我们表明,建立一个两极化的肌动蛋白细胞骨架,无论是作为一正常细胞分裂,或通过激活交配信息素反应抑制蛋白质合成和增长.我们指出总的和单个细胞分析,在不受干扰的情况下不同细胞周期的增殖情况不桶,两极化的时候生长放缓.我们的研究揭示的一个基本关系,细胞周期决定细胞增殖.

The rate of cell growth is governed by cell cycle stage
    Cell growth is an essential requirement for cell cycle progression. While it is often held that growth is independent of cell cycle position, this relationship has not been closely scrutinized. Here we show that in budding yeast, the ability of cells to grow changes during the cell cycle. We find that cell growth is faster in cells arrested in anaphase and G1 than in other cell cycle stages. We demonstrate that the establishment of a polarized actin cytoskeleton—either as a consequence of normal cell division or through activation of the mating pheromone response—potently attenuates protein synthesis and growth. We furthermore show by population and single-cell analysis that growth varies during an unperturbed cell cycle, slowing at the time of polarized growth. Our study uncovers a fundamental relationship whereby cell cycle position regulates growth.

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