在生物学是否存在一个协调后生动物细胞增长和细胞周期的内在的机制是一个长期存在的问题. 我们研究总淋巴母细胞中细胞的大小分布,应用数学分析,计算细胞大小和细胞周期为何都有不同的增值率,我们的结果表明,初期生长抑制期后,在G1之间有一个飞速生长时期,呈指数增殖.细胞分裂可能随着细胞大小和年龄的不同而出现差异. 我们得出这样的结论:哺乳动物细胞增殖有一个保持细胞的大小内在的机制.

Cell Growth and Size Homeostasis in Proliferating Animal Cells
    A long-standing question in biology is whether there is an intrinsic mechanism for coordinating growth and the cell cycle in metazoan cells. We examined cell size distributions in populations of lymphoblasts and applied a mathematical analysis to calculate how growth rates vary with both cell size and the cell cycle. Our results show that growth rate is size-dependent throughout the cell cycle. After initial growth suppression, there is a rapid increase in growth rate during the G1 phase,   followed by a period of constant exponential growth. The probability of cell division varies independently with cell size and cell age. We conclude that proliferating mammalian cells have an intrinsic mechanism that maintains cell size.

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