背景：先前研究发现在心房纤维颤动(AF)病人中血浆C 反应蛋白（CRP）水平升高.在本研究中大部分的心房纤维颤动病人有其他多种心脏病,但是我们的研究主要是检测伴随有AF的特发性扩张型心肌病(IDCM)病人的CRP水平.材料和方法：242个伴随有AF的IDCM病人的CRP水平与280个对照IDCM病人的CRP水平进行对比,在对照组中,70个有房性过早搏动或前房心动过速,210个有正常窦性心律.与对照组相比CRP水平在AF组中较高,在IDCM病人中随着CRP水平的升高AF病人的百分率升高,同时具有高水平血浆CRP水平的病人很有可能得AF.经过多重逻辑回归分析发现体重指数、AF、和白细胞数量与血清CRP水平紧密相关.结论：伴随有AF的IDCM病人的CRP水平比没有AFD IDCM病人低,同时在IDCM病人中随着CRP水平的升高AF病人增加.这揭示在IDCM病人中可以引发AF病.

1: Clin Cardiol. 2009 Jul 30. [Epub ahead of print
  C-Reactive Protein and Atrial Fibrillation in Idiopathic Dilated Cardiomyopathy.
  Dai S, Zhang S, Guo YH, Chu J, Hua W, Wang FZ.
  Center for Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Street 167, Xicheng District, Beijing 100037, P.R. China.
  BACKGROUND: Previous studies have found elevated plasma C-reactive protein (CRP) levels in atrial fibrillation (AF) patients. Most of these studies included AF patients with various heart diseases, but few studies were designed to investigate CRP in idiopathic dilated cardiomyopathy (IDCM) patients with AF. METHOD AND RESULTS: CRP levels in 242 IDCM patients with AF were compared with CRP levels in 280 control IDCM patients. Among control patients, 70 had atrial premature beats or atrial tachycardia and 210 had normal sinus rhythm. CRP was higher in the AF group than in the control group (median, 4.59 versus 2.81 mg/L; p < 0.001). The prevalence of AF in IDCM patients increased as plasma CRP levels increased, and the patients with the highest plasma CRP levels had the highest probability of suffering from AF. Outcome of multivariate logistic regression analysis showed body mass index, AF, and white blood cell count significantly correlated with the plasma CRP levels. CONCLUSION: Our data demonstrated that the plasma CRP level in IDCM patients with AF was higher than in IDCM patients without AF, and an increase in plasma CRP levels was associated with an increased prevalence of AF in IDCM patients. Also, body mass index, AF, and white blood cell count correlate with plasma CRP levels in IDCM patients. These data suggest there is presence of inflammation in IDCM patients with AF. Copyright (c) 2009 Wiley Periodicals, Inc.
  PMID: 19645035 [PubMed - as supplied by publisher]

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