和超声波一样，产妇血清筛选是早期诊断胎儿畸形的最初手段。根据临床统计结果，作者评估了α胎儿蛋白和β-绒毛膜促性腺激素胎儿在胎儿中枢神经系统、心脏、前腹壁、泌尿道等畸形以及唐氏综合症中的值。在怀孕15-15周胎儿中，前腹壁畸形和中枢神经系统畸形中证实了α胎儿蛋白数值的准确性，在及唐氏综合症中同样也证实了绒毛膜促性腺激素数值的准确性。

 Klin Lab Diagn. 2009 Jun;(6):39-41.

[Article in Russian]

[No authors listed]

Along with ultrasonography, maternal serum screening is an initial stage of a diagnostic process of genetically determined fetal malformation. Based on the performed clinical and statistical study, the author estimated the values of alpha-fetoprotein and beta-subunit of chorionic gonadotropin if the fetus has malformations of the central nervous system, heart, anterior abdominal wall, and urinary tract and Down\'s syndrome. The informative value of alpha-fetoprotein was confirmed in malformations of the anterior abdominal wall (gastroschisis, omphalocele) and the central nervous system (hydrocephalus, spinal hernia) and that of chorionic gonadotropin in Down\'s syndrome in a fetus of 15 to 24 weeks gestation.