摘要: microRNA如何对心脏细胞系的分化和增殖进行控制

    博川报道:约三年前,迪帕克斯塔瓦实验室的成员各自单独进行两个microRNA项目,microRNA是调节基因的小分子.一些研究人员试图找出在早期心脏祖细胞出现的microRNA-145的作用;另外一些人认为microRNA–143具有高度保守性,对于可分化成心肌祖细胞的小鼠胚胎干细胞来说,microRNA–143比其他microRNA表达丰度更高.但是,他们不知道就在同一时间,旧金山的格拉德斯通心血管疾病研究所的研究人员发现了一种单一的microRNA (miRNA的)能有效地转变多能细胞系为血管平滑肌细胞(VSMCs)系.
    这两个miRNA调控蛋白质,同时也被蛋白质所调控,从而引起平滑肌细胞的分化和增殖.这不仅有可能应用于心脏病治疗或开发重新编程细胞的技术,而且还提供了一个不同寻常的研究蛋白质如何调节细胞的命运蓝图.

博川推荐原文检索:
Add microRNA to make smooth muscle
How a pair of microRNAs control differentiation and proliferation in a heart-cell lineage
    About three years ago, members of Deepak Srivastava\'s lab were pursuing separate projects on two microRNAs, which are short molecules that regulate genes. Some researchers were trying to figure out the role of microRNA-145, which had turned up in screens of early cardiac progenitor cells. Others were looking at microRNA-143, which is highly conserved and more abundant than any other microRNA in mouse embryonic stem cells that are differentiating into cardiac progenitors.
    Though they didn\'t know it at the time, these researchers at the Gladstone Institute of Cardiovascular Disease in San Francisco were on their way to uncovering a single microRNA (miRNA) that efficiently shifts multipotent cells into another lineage — in this case vascular smooth muscle cells (VSMCs).
    Both miRNAs regulate and are regulated by proteins that cause the differentiation and proliferation of smooth muscle cells. Not only could this have applications for treating heart disease or developing technologies for reprogramming cells, but also the study provides an unusually complete picture of how miRNAs can regulate cell fate.
原文链接"A key step for the future will be to identify the cellular pathways that are affected by these cyclic peptide原:
http://www.nature.com/stemcells/2009/0907/090709/full/stemcells.2009.92.html

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